FDA Adds More Drugs to List of Those that Combine with Glyburide to Cause Hypos

Page changed: Metformin, Acarbose, and Drugs that Stimulate Insulin Secretion

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The following drugs are known to increase the effect of sulfonylurea drugs which can cause dangerous hypos:

Nonsteroidal anti-inflammatory drugs [Ibuprofen, Motril, Advil etc], clarithromycin, and other drugs that are highly protein bound, such as salicylates [aspirin], sulfonamides [Septra, Bactrim, etc], chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, and ß-adrenergic blocking agents [Beta Blockers like Toprol and others].

In August of 2009 The FDA added a new warning about combining Glyburide with disopyramide [Norpace], fluoxetine [Prozac], and quinolones [Cipro and other "floxin" antibiotics].