This blog tracks updates to the Blood Sugar 101 Web site.

Wednesday, May 27, 2009

Reference Removed: Metformin May Prevent Beta Cell Apoptosis

Page Changed: Metformin, Acarbose, Sulfonylureas: The Truth About Oral Diabetes Drugs

Removed citation to human pancreas autopsy study with findings that metformin might help prevent beta cell apoptosis (cell suicide). Reading the full study made it clear that the researchers were not discussing the actual impact of metformin taken as a drug on humans, but instead describing a highly artificial situation created in cultured cells taken from dead pancreata and bathed in fat and a metformin solution.

This is the study:
Autophagy in human type 2 diabetes pancreatic beta cells M. Massini et al. Diabetologia Volume 52, Number 6 / June, 2009, DOI 10.1007/s00125-009-1347-2.Pages 1083-1086

New Evidence on How Metformin Works

Page Changed: The Truth about Oral Diabetes Drugs

Added citation to new study which suggests that metformin stops the liver from dumping glucose by directly stimulating a gene in the liver which should be stimulated by insulin but in many Type 2s apparently isn't. This suggests that it isn't lowering insulin resistance so much as doing the job itself insulin isn't doing.

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein Ling He et al,, Cell Volume 137, Issue 4, 635-646, 15 May 2009. doi:10.1016/j.cell.2009.03.016

This is explained in layman's language in this week's release of Diabetes in Control:

New Information on how Metformin works. Diabetes in Control May 27, 2009.

Tuesday, May 5, 2009

Google Search box added to Foot of Blood Sugar 101 Pages

Pages Changed: Most

The site has grown huge over the past several years so to help you find what you are looking for, I've put a Google Search box on the bottom of every page. It's set up to default to search the site.

Monday, May 4, 2009

Pesticide Atrazine Maps to Obesity and Causes IR and Weight Gain Even Without Dietary Change

Page Changed: You Did Not Eat Your Way to Diabetes

Added cite to new study which found that the herbicide Atrazine, the use of which maps closely to the prevalence of obesity in the U.S., causes insulin resistance, weight gain and mitochondrial dysfunction in rats who get a lot concentration of it in their water. The weight gain is independent of diet, though a high fat/high carb diet leads to more weight gain.