Page Changed: Metformin, Acarbose, Sulfonylureas: The Truth About Oral Diabetes Drugs
Removed citation to human pancreas autopsy study with findings that metformin might help prevent beta cell apoptosis (cell suicide). Reading the full study made it clear that the researchers were not discussing the actual impact of metformin taken as a drug on humans, but instead describing a highly artificial situation created in cultured cells taken from dead pancreata and bathed in fat and a metformin solution.
This is the study:
Autophagy in human type 2 diabetes pancreatic beta cells M. Massini et al. Diabetologia Volume 52, Number 6 / June, 2009, DOI 10.1007/s00125-009-1347-2.Pages 1083-1086
Showing posts with label metformin. Show all posts
Showing posts with label metformin. Show all posts
Wednesday, May 27, 2009
New Evidence on How Metformin Works
Page Changed: The Truth about Oral Diabetes Drugs
Added citation to new study which suggests that metformin stops the liver from dumping glucose by directly stimulating a gene in the liver which should be stimulated by insulin but in many Type 2s apparently isn't. This suggests that it isn't lowering insulin resistance so much as doing the job itself insulin isn't doing.
Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein Ling He et al,, Cell Volume 137, Issue 4, 635-646, 15 May 2009. doi:10.1016/j.cell.2009.03.016
This is explained in layman's language in this week's release of Diabetes in Control:
New Information on how Metformin works. Diabetes in Control May 27, 2009.
Added citation to new study which suggests that metformin stops the liver from dumping glucose by directly stimulating a gene in the liver which should be stimulated by insulin but in many Type 2s apparently isn't. This suggests that it isn't lowering insulin resistance so much as doing the job itself insulin isn't doing.
Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein Ling He et al,, Cell Volume 137, Issue 4, 635-646, 15 May 2009. doi:10.1016/j.cell.2009.03.016
This is explained in layman's language in this week's release of Diabetes in Control:
New Information on how Metformin works. Diabetes in Control May 27, 2009.
Tuesday, October 28, 2008
New Large Study: Metformin Does Not Cause Lactic Acidosis
page changed: The Truth About Oral Diabetic Drugs
Added link to new study published in Diabetes Care which provides strong evidence that metformin does not raise the risk of lactic acidosis in people who take it and that, in fact, it is safer in this regard than suflonylurea drugs (Amaryl, glipizide, glyburide, etc.)
Added link to new study published in Diabetes Care which provides strong evidence that metformin does not raise the risk of lactic acidosis in people who take it and that, in fact, it is safer in this regard than suflonylurea drugs (Amaryl, glipizide, glyburide, etc.)
Friday, September 12, 2008
UKPDS Followups: Metformin's Effects over 20 year Period
Page Changed: The Truth About Oral Diabetic Drugs.
Added data from the 20-year follow up to the UKPDS showing that in a group of patients who at one time had attempted to achieve a 7% A1c (eating a very high carb diet) but over time failed to maintain even that low a blood sugar, those using Metformin had less complications and one third less heart attacks.
Added data from the 20-year follow up to the UKPDS showing that in a group of patients who at one time had attempted to achieve a 7% A1c (eating a very high carb diet) but over time failed to maintain even that low a blood sugar, those using Metformin had less complications and one third less heart attacks.
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