Page changed: Metformin, Acarbose, and Drugs that Stimulate Insulin Secretion
Added this text:
The following drugs are known to increase the effect of sulfonylurea drugs which can cause dangerous hypos:
Nonsteroidal anti-inflammatory drugs [Ibuprofen, Motril, Advil etc], clarithromycin, and other drugs that are highly protein bound, such as salicylates [aspirin], sulfonamides [Septra, Bactrim, etc], chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, and ß-adrenergic blocking agents [Beta Blockers like Toprol and others].
In August of 2009 The FDA added a new warning about combining Glyburide with disopyramide [Norpace], fluoxetine [Prozac], and quinolones [Cipro and other "floxin" antibiotics].
Wednesday, August 26, 2009
Wednesday, August 19, 2009
Cancer Treatment and Especially Radiation Cause Diabetes Independent of BMI or Exercise
Page Changed: You Did Not Eat Your Way To Diabetes
Added citation and discussion of a new large population study that found that after adjusting for BMI and exercise, there was almost double the incidence of diabetes in survivors of childhood cancer and a 7.2 times greater risk of diabetes among cancer survivors who had been treated with full body radiation.
This raises the question about whether other exposures to radiation might be a contributing cause of diabetes, especially the very high doses used in CAT scanning.
Diabetes Mellitus in Long-term Survivors of Childhood Cancer: Increased Risk Associated With Radiation Therapy: A Report for the Childhood Cancer Survivor Study.Lillian R. Meacham et al. Arch. Int. Med.Vol. 169 No. 15, Aug 10/24, 2009.
Added citation and discussion of a new large population study that found that after adjusting for BMI and exercise, there was almost double the incidence of diabetes in survivors of childhood cancer and a 7.2 times greater risk of diabetes among cancer survivors who had been treated with full body radiation.
This raises the question about whether other exposures to radiation might be a contributing cause of diabetes, especially the very high doses used in CAT scanning.
Diabetes Mellitus in Long-term Survivors of Childhood Cancer: Increased Risk Associated With Radiation Therapy: A Report for the Childhood Cancer Survivor Study.Lillian R. Meacham et al. Arch. Int. Med.Vol. 169 No. 15, Aug 10/24, 2009.
Actos Raises Fracture Risk 77% in Women 61% in Men
Page Changed: Actos and Avandia Dangerous Diabetes Drugs
Added study analyzing data from 84 339 patients from British Columbia, Canada, who began treatment with a thiazolidinedione or a sulfonylurea. The study found that use of Actos conferred a 77% higher risk of periphereral fracture (i.e. broken bones in arms and legs) for women and a 61% higher risk for men.
Thiazolidinediones and fractures in men and women. Dormuth CR, et al. Arch Intern Med. 2009 Aug 10;169(15):1395-402.
Despite overwhelming evidence from many studies cited on this page, doctors still call for "more study." While they are studying, patients taking Actos and Avandia are having their osteocytes--baby bone cells--converted to fat cells, which over time makes bones porous and prone to break. Reversing this damage once it occurs may be impossible, or a very slow process.
Added study analyzing data from 84 339 patients from British Columbia, Canada, who began treatment with a thiazolidinedione or a sulfonylurea. The study found that use of Actos conferred a 77% higher risk of periphereral fracture (i.e. broken bones in arms and legs) for women and a 61% higher risk for men.
Thiazolidinediones and fractures in men and women. Dormuth CR, et al. Arch Intern Med. 2009 Aug 10;169(15):1395-402.
Despite overwhelming evidence from many studies cited on this page, doctors still call for "more study." While they are studying, patients taking Actos and Avandia are having their osteocytes--baby bone cells--converted to fat cells, which over time makes bones porous and prone to break. Reversing this damage once it occurs may be impossible, or a very slow process.
Study Confirms Benefits of Insulin/Metformin Regimen for Newly Diagnosed Type 2s
Page changed: Insulin for Type 2 Diabetes
Added link to new article which compared three years of using an Insulin with metformin regimen with a metformin, pioglitazone (Actos), and glyburide regimen. Patients had nearly identical results with less average weight gain and no more hypos in the insulin group and high patient satisfaction with insulin.
It's heartening to see that the average A1c in both groups of this study was in the very low 6% range which is a huge improvement on what we usually see in such studies.
Added link to new article which compared three years of using an Insulin with metformin regimen with a metformin, pioglitazone (Actos), and glyburide regimen. Patients had nearly identical results with less average weight gain and no more hypos in the insulin group and high patient satisfaction with insulin.
It's heartening to see that the average A1c in both groups of this study was in the very low 6% range which is a huge improvement on what we usually see in such studies.
Monday, August 17, 2009
Lantus and Cancer: Discussion Added to Site
Page Changed: Insulin for Diabetes
Added discussion of the controversy surrounding whether Lantus promotes cancer including links to the original Diabetologia studies raising the question, the Diabetes Update blog post discussing this question, and a subsequent large study finding that casts further doubt on the theory.
Added discussion of the controversy surrounding whether Lantus promotes cancer including links to the original Diabetologia studies raising the question, the Diabetes Update blog post discussing this question, and a subsequent large study finding that casts further doubt on the theory.
Wednesday, August 12, 2009
New MODY Gene Identified
Page changed: MODY It's Not Type 1 or Type 2 but Something Else
Added link to study identifying a new MODY gene, BLK, which affects the ability to secrete insulin.
For more discussion of this discovery, please read this Diabetes Update blog post: Diabetes Update: New MODY Gene Identified.
Note the second link in the blog post should go to THIS LINK.
Blogger is not letting me get into my Diabetes Update blog control panel this afternoon so I have not been able to fix it or approve comments.
Added link to study identifying a new MODY gene, BLK, which affects the ability to secrete insulin.
For more discussion of this discovery, please read this Diabetes Update blog post: Diabetes Update: New MODY Gene Identified.
Note the second link in the blog post should go to THIS LINK.
Blogger is not letting me get into my Diabetes Update blog control panel this afternoon so I have not been able to fix it or approve comments.
Wednesday, August 5, 2009
Prozac and Cipro can Cause Dangerous Hypos when Combined with Sulfs like Amaryl
Page changed: Metformin, Acarbose and Drugs that Stimulate Insulin Secretion
Added information about new FDA warnings (added to required Prescribing Information) about other drugs that have been found to interact with Sulfs like Amaryl and Glipizide in ways that can cause dangerous hypos. These drugs include Prozac and Cipro as well as others.
A warning is also added about interactions of Lopid and cyclosporin with Prandin.
FDA Safety Alerts (7/11/09)
Added information about new FDA warnings (added to required Prescribing Information) about other drugs that have been found to interact with Sulfs like Amaryl and Glipizide in ways that can cause dangerous hypos. These drugs include Prozac and Cipro as well as others.
A warning is also added about interactions of Lopid and cyclosporin with Prandin.
FDA Safety Alerts (7/11/09)
Monday, August 3, 2009
Onglyza: Just Like Januvia--But Worse
Page Added: Onglyza - Just Like Januvia, but Worse
Added review of FDA required Prescribing Information for newly approved DPP-4 inhibitor, Onglyza. Text of page is the same as August 3 Diabetes Update blog post on same topic.
Added review of FDA required Prescribing Information for newly approved DPP-4 inhibitor, Onglyza. Text of page is the same as August 3 Diabetes Update blog post on same topic.
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