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Wednesday, March 13, 2013

NSAIDS Taken with ACE Inhibitors and Diuretics Dramatically Increase Risk of Kidney Damage

Page Changed: Other Dangerous Drugs for People with Diabetes

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Mixing NSAIDS with Diuretics and ACE Inhibitors Is Even More Damaging to the Kidney

A study published in the British Medical Journal found that:
The results show that patients taking a double therapy combination of either a diuretic or an ACE inhibitors or ARB with an NSAID were at no increased risk of kidney injury. However, a triple therapy combination of a diuretic with an ACE inhibitor or ARB and an NSAID was associated with a 31% higher rate of kidney injury, particularly elevated in the first 30 days of treatment during which it was 82% higher.
Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. Francesco Lapi, Laurent Azoulay, Hui Yin, Sharon J Nessim, Samy Suissa. BMJ, 2013 DOI: 10.1136/bmj.e8525.
Explained by Science Daily HERE.

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