This blog tracks updates to the Blood Sugar 101 Web site.

Sunday, December 7, 2008

Study Calls DPP-4 Inhibition "Trigger" for Prostate Cancer

Page Changed: Januvia

Januvia works by inhibiting DPP-4, an enzyme which is used all over the body for many different purposes, many of which are unrelated to blood sugar. The study cited here is one of several recent studies that find that inhibiting DPP-4 leads cells of various types to turn cancerous.

Other cells that become cancerous with to DPP-4 inhibition are melanocytes and ovarian cells.

Here is the study: Note the conclusion:

CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12.

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