This blog tracks updates to the Blood Sugar 101 Web site.

Tuesday, December 9, 2008

Gene Raises Risk of Heart Disease in People With Diabetes And Magnifies the Positive Impact of Very Tight Control

Page Changed: A1c and High Post-Meal Blood Sugars Predict Heart Attack.

Added reference to study published in JAMA linking doubled risk of heart disease to possession of a single copy of a specific gene defect and quadrupled risk to having two copies.

The study finds that "good control" halves the incidence of heart disease in people with the gene. However, "good control" here, as always, is defined as the mediocre 7% A1c that is associated with a much higher risk of heart attack in ALL populations.

This suggests that lowering blood sugar to a truly safe level--the 5-6% A1c range would provide even greater benefits to people with this gene.

Interaction Between Poor Glycemic Control and 9p21 Locus on Risk of Coronary Artery Disease in Type 2 Diabetes
Alessandro Doria et al. JAMA, 2008;300(20):2389-2397.

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