Avandia and Actos Removed from Oral Diabetes Drug Page

Page Changed: The Truth About Oral Diabetes Drugs
New Page Added: Actos and Avandia

Today's news included analysis of a study that had gone beneath the radar when initially published in Diabetes Care's online edition on May 29. This study found that Avandia and Actos both appeared to cause heart failure in younger people who took it who did not have preexisting heart failure. It also found one in fifty patients taking either of these drugs were hospitalized for heart failure.

I made the decision to remove Avandia and Actos from the list of legitimate oral diabetes drugs because there is now just too much evidence that neither of these drugs is effective enough to justify the risk of heart failure, macular edema, permanent weight gain, and osteoporosis that they cause.

Also, I have removed from this page some of the more historical information about Rezulin and the detailed discussion of the TRIPOD study involving Rezulin which was used to support the idea that this class of drugs could rejuvenate beta cells. This premise was proven to be false by the DREAM study, so my questioning of the conclusions drawn from the TRIPOD data was correct, however, the DREAM study results make the lengthy analysis of the earlier study unnecessary.

FDA Report Damns Avandia and Glaxo's Intimidation of Whistleblower

Page Updated: The Truth about Oral Diabetes Drugs

Links to the blog entry detailing Glaxo's intimidation in 1999 of a researcher who discovered the Avandia/heart failure link.

Link to coverage of today's FDA Report emphasizing heart danger of Avandia and confirming above report of whistleblower intimidation and calling Glaxo's claim that a new study would show Avandia to be safe "False."

Byetta and Januvia Page Split into Two Separate Pages

Page changed: Byetta and Januvia

This page has been split into two pages.

Information about Byetta has been moved to a new page entitled "Byetta" at http://www.phlaunt.com/diabetes/18538438.php

Information about Januvia has been moved to a new page entitled "Januvia" at http://www.phlaunt.com/diabetes/18538604.php

In addition, I've edited the Januvia page to eliminate out-of-date material.

7/22 Changes to Byetta and Januvia Page

Page Changed: Byetta and Januvia
Added reference to a study showing higher DPP-4 correlates with less inflammation in Rheumatoid arthritis in mouse and human subjects.

Added link to page that tracks all journal studies of DPP-4 with handy link to abstracts.

Added second report of rash associated with Januvia that was mailed to me.

July 18

Page Changed: From Normal to Diabetic

New study published in Diabetes Care finds development of diabetes diagnosed by fasting plasma glucose within 3 years of two fasting readings over 100 mg/dl. Report from Diabetes in Control, as article is not yet available online.

Also:

Page Changed: You Did NOT Eat Your Way To Diabetes

Added link to another study published in 2006 by Shulman at Yale Medical School looking at mitochondrial dysfunction in lean people with IR. (Footnote 5)

July 17 - New Study Shows IR precedes Obesity and Involves Abnormal Glucose Metabolism

UPDATED PAGE: You Did Not Eat Your Way To Diabetes
Added a summary of brand new study published in PNAS (and not yet available online), based on a press release. This study which showed lean people with insulin resistance turned high carb meals into triglycerides while lean people with insulin sensitivity stored the glucose from the high carb meal as glycogen

Researchers point out that IR is clearly not being caused by obesity in this situation but precedes it and is characterized by a tendency to store energy as fat.

http://www.phlaunt.com/diabetes/14046739.php

Changes to "Insulin for Type 2" Page

Added: information about rare hypos caused by Lantus shot into a blood vessel. Added reference to Novolog in discussion of Analog insulins.
http://www.phlaunt.com/diabetes/15478720.php

New Page: Miracle Foods?

Deconstructing the research that makes poorly supported health claims about "healing foods". Contains material previously published as entries on the Diabetes Update blog
http://www.phlaunt.com/diabetes/18433429.php

Updated 7/10/07

Today's updated page: Supplements for Diabetes

Information about the study connecting Selenium and a higher rate of developing Type 2 diabetes.