This blog tracks updates to the Blood Sugar 101 Web site.


Friday, October 28, 2011

Free Antibody Testing Available for People with Family Members Diagnosed with Type 1

Page Changed: LADA

Added the following:

Free Antibody Testing Available from TrailNet

An organization called Type 1 Diabetes TrialNet is sponsoring several studies which offer those with relatives diagnosed with Type 1 the opportunity to get free antibody testing. Those who have already tested positive for the antibodies can be enrolled in studies involving experimental treatments intended to delay the destruction of beta cells.

To be eligible for the screening test you must meet one of the following criteria:
  • 1 to 45 years of age and have a brother, sister, child, or parent with type 1 diabetes

  • 1 to 20 years of age and have a cousin, aunt, uncle, niece, nephew, half sibling, or grandparent with type 1 diabetes
More information about the TrialNet screening and studies can be found at:
Type 1 Diabetes TrialNet: Information for Study Participants

Sunday, October 16, 2011

Added Discussion of The Toxic Effect of ACCORD Study Misinterpretations to the Blood Sugar Targets Page

Page Changed: Healthy Blood Sugar Targets

Added the following text:

But My Doctor Says Lowering Blood Sugars is Dangerous

If you are told that lowering your blood sugars is dangerous or can cause a heart attack, the chances are that your doctor read about a study called ACCORD in a newsletter. This was a study that followed a large group of people who attempted to reach an A1c of 6.5. It was reported as concluding that those who achieved the lower A1c had a slightly higher risk of heart attack.

Subsequent analysis of the ACCORD data found two things:

  • Those who had heart attacks were those in the group attempting to lower A1c who did not achieve the lower blood sugars, and
  • The excess heart attacks occurred in those who took Avandia, a drug now known to raise heart attack risk.

Unfortunately, though the original finding received a great deal of press, the subsequent analyses explaining the result did not.

The only other study that found a problem with lowering A1c was in a group of elderly veterans who were also using the sulfonylurea drugs glipizide and glimepiride, two drugs that, like Avandia and Actos, have also been found to damage the heart over time.

There is not a single piece of research, anywhere, that suggests it's harmful to lower blood sugar by cutting down on carbohydrates. In addition, there's a lot of research suggesting that lowering blood sugars without the use of the drugs known to be harmful to the heart prevents or reverses neuropathy, retinal damage, and heart disease.

For further insight into ACCORD and links to the actual research visit:

Diabetes Update: ACCORD Redux, It's the High Blood Sugars Stupid

Diabetes Update: Avandia is sufficient to explain the excess deaths in ACCORD

You can learn more about this issue by typing "ACCORD" into the Google Search box at the upper left corner of this page.

Wednesday, October 5, 2011

New Study Confirms that Post-Meal Sugars and A1c Predict Heart Disease & Mortality

Page changed: A1c and High Post-Meal Blood Sugars Predict Heart Attack

Moved discussion about cholesterol as a predictor of heart attack to the bottom of the page and edited it.

Added the following:

Post-Meal Blood Sugar and A1c Predict Cardiovascular Events and Deaths

A study conducted in Italy which analyzed 14 years of blood sugar data taken from people recently diagnosed with Type 2 diabetes concluded "A1C and blood glucose 2 h after lunch but not FBG [fasting blood glucose] predict cardiovascular events and all-cause mortality." The reason only sugars after lunch were cited here is that the study did not analyze post-dinner readings, only pre-dinner readings. The methodology of this study was crude--basically they compared people who met the anemic ADA blood sugar targets with those who didn't, classifying those with post-meal readings under 180 mg/dl (10 mmol/L) as "good" and comparing them with those that were over and hence "bad." Even with this crude filter, the post-meal reading was predictive.

Postprandial Blood Glucose Predicts Cardiovascular Events and All-Cause Mortality in Type 2 Diabetes in a 14-Year Follow-Up Lessons from the San Luigi Gonzaga Diabetes StudyFranco Cavalot et al. Diabetes Care October 2011 vol. 34 no. 10 2237-2243.doi: 10.2337/dc10-2414

Friday, September 2, 2011

New Page Added: Charcot's Foot

Page added: Charcot's Foot


Charcot's Foot: A Foot Complication Caused by Clogged Blood Vessels


Most of us know that people with diabetes are prone to getting clogged arteries. But this is often portrayed as being caused by a build up of cholesterol in the large arteries of the heart, which doctors treat by prescribing statins. (Whether this works is discussed in great detail HERE.)

But what most people with diabetes don't understand is that damage to your blood circulation which causes the worst diabetic complications comes not from having high cholesterol, but from the toll high blood sugars take on the tiny capillaries that carry blood, oxygen, and immune system cells throughout all our tissues, including our nerves, bones, tendons, kidneys, and retinas.

Prolonged exposure to high blood sugars cause sugars to bond to the walls of tiny blood vessels which stiffen and narrow to where blood and immune system cells can't pass through them. Over time capillaries become incapable of carrying nutrients to your cells. Nerves die when capillaries don't bring them enough oxygen and nutrients. Tendons become brittle, kidneys stop filtering our urine, retinas grow a tangled network of fragile new blood vessels to replace the ones that don't work which rupture, causing blindness, and feet become gangrenous.

But one of the more serious diabetic complications that afflicts those who have experienced years of exposure to very high blood sugars--and one that few people know about, including many doctors--is Charcot's Foot.

In this condition, the long bones of the foot which have been deprived of nutrients because of damage to the circulatory system (and possibly to the nerves) break, causing the foot to collapse. This condition is crippling and can lead to gangrene because damage to the circulatory system also keeps the immune system from sending infection-fighting cells to the foot.

This complication usually occurs only after you have experienced decades of exposure to very high blood sugars. So if you are newly diagnosed it isn't something to worry about every time you feel a twinge in your foot. But it is a very good reason to ensure that you don't expose your circulatory system to decades of exposure to blood sugars that can cause this kind of damage.

Keeping your blood sugars under 140 mg/dl at all times will prevent this and other complications from developing. You can learn more about how you can do this, and join many thousands of people with diabetes who have already done this, by following the technique you'll see described HERE.

But you have already had diabetes for a decade or more and have been a victim of mediocre care that let you maintain fasting blood sugars well over 140 mg/dl and A1cs above 7% or worse, damage to your bones may be underway. If so, take foot pain seriously and get help. Many family doctors are not familiar with this complication and may ignore it until you have no option left but amputation.

Help is available, even if Charcot's Foot is developing. Dr. Richard K. Bernstein reports in his book, Dr. Bernstein's Diabetes Solution:
that he reversed early changes associated with this complication by lowering his blood sugar to normal levels.

Even if your foot has progressed to where you have been told you need an amputation because of the damage to your bones, there are clinics that specialize in preventing amputation, and they are having success in treating Charcot's Foot with new treatments that can preserve your foot.

You can read about Charcot's Foot and the treatments that can heal it in this excellent article:

Science Daily: Crippling Condition Associated With Diabetes Is Often Misdiagnosed and Misunderstood.

The article in Diabetes Care cited in the Science Daily article, which discusses this condition in more technical terms, can be found at the link below.The full text should be available for free after April 1, 2012.

The Charcot Foot in Diabetes. Lee C. Rogers, et al., Diabetes Care September 2011 34:2123-2129

Monday, July 11, 2011

NSAIDS Linked to Increased Incidence of Atrial Fibrillation Especially in People with Kidney Disease

Page Changed: Other Dangerous Drugs for People with Diabetes

Added the following:

NSAIDS (Advil, Ibuprofen, Celebrex, etc.) Linked to Higher Risk of Atrial Fibrillation

Evidence from a study of 32,602 patients from the Danish National Registry found that a history of taking first generation Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) such as Advil or ibuprofen was associated with a 40% higher risk of developing an abnormal heart rhythm.The newer COX-2 inhibitors like Celebrex were associated with a 70% higher risk.The risk was greatest for older people and people with kidney disease. This makes it likely that these drugs are more dangerous for people with Diabetes, many of whom have signs of kidney damage.

Non-steroidal anti-inflammatory drug use and risk of atrial fibrillation or flutter: population based case-control study. M. Schmidt, et al. BMJ, 2011; 343 (jul04 1): d3450 DOI: 10.1136/bmj.d3450

Discussed in detail here:

Science Daily: Common Pain Killers Linked to Irregular Heart Rhythm

Friday, June 24, 2011

Kombiglyze and Tradjenta--Ineffective, Expensive, DPP-4 Inhibitors with Scary Side Effects

Page Changed: Onglyza, Kombiglyze, Tradjenta -- Just like Januvia but Worse

Added the following:

Onglyza is now being being marketed as Kombiglyze, a pill that combines Onglyza and Metformin. Easily swayed doctors are therefore prescribing to newly diagnosed patients only the very expensive combo pill instead of the extremely cheap generic Metformin pill. Don't let your doctor prescribe this combo drug.

And added this:

As of Summer 2011 there is yet another FDA-approved DPP-4 inhibitor drug available that is very similar to Onglyza. It is named Tradjenta. Based on its prescribing information, which you can read HERE, it it shares with Onglyza the characteristics that it makes very little change in blood sugar, costs a fortune, and causes the same significant immune-system related side effects--most notably the permanent sinus headache/runny nose that is a result of DPP-4 inhibition in the sinues--as well as raising the risk of pancreatitis.

In patients whose A1cs averaged 8.1% and whose fasting blood sugar averaged 178.4 mg/dl Trajenta lowered A1c to a still dangerous average 7.5% and lowered the fasting blood sugar to a rampantly damaging average of 165.1 mg/dl.

You can lower your blood sugar far more just by following the advice you'll find HERE.I have heard from hundreds of people who have done just that without any drugs except generic metformin--or no drugs at all.

Chances are there will soon be a metformin-Trajenta combo drug. Avoid it. If you feel that despite the risks you want to take a DPP-4 inhibitor Januvia appears to be the one that lowers blood sugar the best, though it doesn't do all that good a job of it and will end up giving you significant side effects.

Thursday, June 16, 2011

Actos Associated with Higher Bladder Cancer Risk & FDA Administers Avandia Wrist Slap

Page Changed: Actos and Avandia Dangerous Diabetes Drugs

Added the following text:

In June of 2011 the FDA confirmed that there was a heightened risk of bladder cancer with Actos.

FDA Drug Safety Communication: Update to ongoing safety review of Actos (pioglitazone) and increased risk of bladder cancer

FDA Imposes Tight Restrictions on Avandia Prescribing
In May of 2011 the FDA tightened the restrictions on prescribing Avandia but they did not take it off the market, and doctors can and do still prescribe it. The new restrictions state that patients who are now taking the drug will have to sign an informed consent statement acknowledging that they understand all the risks before they will be allowed to refill their prescriptions and that new patients will not be able to receive the drug unless their doctors certify that they are unable to control their blood sugar levels with other therapies and that medical problems preclude them from taking Avandia's primary competitor, Actos.

As you can see, this means nothing. Doctors who prescribe Avandia will keep on prescribing it. The FDA is not likely to take either of these dangerous drugs off the market until weeks before their patents expire. They are just too profitable.

Avandia (rosiglitazone): REMS - Risk of Cardiovascular Events includes Avandia, Avandamet, and Avandaryl