Study: 15% of Type 2s diagnosed before Age 45 have defects in MODY genes

Page Changed: MODY - It's Not Type 1 and Not Type 2, but Something Else 

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A study of individuals with clinically labeled type 2 diabetes, found that when HNF1A and HNF4A were sequenced in 80 subjects with diabetes diagnosed <=30 years and/or diabetes diagnosed <=45 years without metabolic syndrome 12 of the subjects were found to have mutations in the HNF1A and HNF4A genes suggestive of MODY. This represents 15% of those 80 subjects.

Most significantly, though, of these 12 subjects, only 47% of MODY subjects identified met current guidelines for diagnostic sequencing. This means that if they took the standard MODY tests their mutation would not have been found.

The study concludes, "We recommend that all patients diagnosed before age 30 and with presence of C-peptide at 3 years' duration [be] considered for molecular diagnostic analysis." Note that this is not the same as taking Athena Lab's MODY tests but involves looking at the MODY genes for evidence of any significant defect.

Systematic Assessment of Etiology in Adults With a Clinical Diagnosis of Young-Onset Type 2 Diabetes Is a Successful Strategy for Identifying Maturity-Onset Diabetes of the Young. Gaya Thanabalasingham et al. Diabetes Care Diabetes Care June 2012 vol. 35 no. 6 1206-1212

Updated Page: Studies Proving The Safety and Efficacy of the Low Carb Diet

Page changed: Studies Proving The Safety and Efficacy of the Low Carb Diet

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ou can read detailed discussions of these studies and more, as well as some others that throw light on why many people do have problems with low carb diets, in my new book, Diet 101: The Truth About Low Carb Diets

One Important Warning

When I went back and carefully reread the low carb research discussed on this page while working on my new book I found some new details, and a couple longer lasting studies that pointed up an important fact that did not come out in studies that lasted a year or less.

What they have to teach us is this: Low carb diets are very healthy as long as they are really low carb. But the bad news is that if your carbohydrate intake starts to rise over 120 grams per day, your diets will become very unhealthy unless you cut back on fat. A high fat intake is only healthy with a truly low carb diet.

The studies that convinced doctors in the 1970s that low carb diets were dangerous were all studies of people eating "low carb" diets of 150 grams of carbohydrate a day or more. And more recent research suggests that those diets are just as unhealthy now as they were then.

If you can control your blood sugar with a diet that cuts carbs to a level nearer 150 grams a day, as opposed to 100 grams a day, keep your fats to 30% of all calories and you'll be fine.
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When studies attacking low carb diets involve human subjects, they often draw their conclusions from the analysis of food questionnaires. An example are studies that claim that eating meat leads to terrible health outcomes. What these studies don't do, is ask people what they ate with their meat, which is often supersized fries, soda, and a huge, sugary dessert. They also don't ask them what exactly they meant by "meat." Pink slime burgers infused with a cocktail of powerful chemicals, including MSG, consumed at fast food outlets are very different in their nutritional impact than organic meats or artisanal cheeses served with fresh vegetables. Cutting carbs does not make chemical-laced low quality food healthy, so if you cut your carbs, do what you can to improve the quality of the foods you eat.

New Page Added Linking to Low Carb Nutritional Calculator

Page Added: Low Carb Nutritional Calculator

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Wondering how much protein and fat you should be eating along with the amount of carbs that controls your blood sugar?

You can learn what proportions are healthiest by plugging your numbers into our new nutritional calculator, which you'll find HERE

The calculator will also tell you how many calories you need to eat to achieve specific weight loss goals, based on the newest, and most accurate formulas for calculation your basal metabolic rate. If you know your body fat percentage, the calculator is even more accurate.