Page Changed: SGLT2 Inhibitors, Farxiga, Invokana, Jardiance. Questionable New Drugs
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p >These sodium-glucose co-transporter-2 (SGLT-2) inhibitors lower blood sugar by blocking reabsorption of glucose by the kidney and increasing its excretion in urine. However, recent findings suggest tht though these drugs ramp up excretion of glucose, they also ramp up production of glucose by stimulating the secretion of glucagon. More about that can be read HERE
The Diabetes.co.uk web site describing this class of drugs also says that in the studies used for approving the drug there were more cases of liver failure, breast and bladder cancer, though the effect was not strong enough to block approval of the drug.
Added mention of Invokamet and Xigduo, combination forms of these drugs with metformin.