This blog tracks updates to the Blood Sugar 101 Web site.

Monday, October 21, 2013

Page Changed: MODY It's Not Type 1 or Type 2 but Something Else

Added the following:

MODY forms of diabetes were long believed to affect around 2% of all people diagnosed with both type 1 and type 2 diabetes. However, a study of 586 children diagnosed with Type 1 diabetes found that a full 8% of them were actually carrying one of the three most common MODY genes. It is likely that a similar number of people diagnosed with Type 2 may also have one of these genetic forms of diabetes, too.

Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth. Catherine Pihoker et al.J Clin End & Metab October 1, 2013 vol. 98 no. 10 4055-4062.

Also further down the page in the list of Signs You Don't Have MODY:

  • GAD or Islet Antibodies or Diagnosis of Other Autoimmune Disease These characteristics make it much more likely that you have a form of autoimmune Diabetes, either Type 1 or LADA.

  • and

  • Normal Responses to Type 2 Drugs People with MODY rarely see any significant effect from drugs that lower insulin resistance. At the same time, they have a dramatic response to very low doses of drugs that stimulate insulin secretion like sulfonylurea drugs (glipizide, glimipiride, glyburide etc.) or repaglinide (Prandin).
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